Deep brain stimulation in the treatment of Parkinson's disease: a review and update
Identifieur interne : 000863 ( Main/Corpus ); précédent : 000862; suivant : 000864Deep brain stimulation in the treatment of Parkinson's disease: a review and update
Auteurs : Patricia Dowsey-Limousin ; Pierre PollakSource :
- Clinical Neuroscience Research [ 1566-2772 ] ; 2001.
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- KwdEn :
Abstract
Deep brain stimulation (DBS) is a neurosurgical treatment of severe forms of Parkinson's disease, already applied to three targets, the thalamus, the internal pallidum (GPi) and the subthalamic nucleus (STN). Thalamic DBS mainly improves contralateral tremor and is therefore restricted to a small group of patients with tremor dominant disease. STN and GPi DBS improve off-motor periods and dyskinesias. The magnitude of the improvement seems more constant with STN DBS than with GPi, but there is very little comparative data between these procedures. The DBS procedure has the unique advantage of reversibility and adjustability over time. Most authors agree that bilateral DBS is reasonably safe, which is not the case of ablation. In any event, surgery is restricted to patients disabled by their condition but still responding well at times to levodopa, who are generally fit with no behavioural, mood or cognitive impairment. DBS can have side effects. Side effects more specific to the DBS procedure are infection, disconnection and hardware failure. DBS, like ablative surgery can induce an intracranial lesion like a hematoma or a stroke. There are side effects more specific to the target like postural instability, dysarthria or paresthesia in the thalamus and dyskinesias or eyelid opening apraxia in the STN. The mechanism by which high frequency DBS mimics the effect of ablation is not fully understood.
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DOI: 10.1016/S1566-2772(01)00029-9
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Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, BP 217, 38043 Grenoble Cedex 9, France. Tel.: +33-476765791; fax: +33-476765631</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: pierre.pollak@ujf-grenoble.fr</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DB8891786BF537B5B60452C25BC70502061DF52E</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1016/S1566-2772(01)00029-9</idno><idno type="url">https://api.istex.fr/document/DB8891786BF537B5B60452C25BC70502061DF52E/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000863</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Deep brain stimulation in the treatment of Parkinson's disease: a review and update</title><author><name sortKey="Dowsey Limousin, Patricia" sort="Dowsey Limousin, Patricia" uniqKey="Dowsey Limousin P" first="Patricia" last="Dowsey-Limousin">Patricia Dowsey-Limousin</name><affiliation><mods:affiliation>Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, WC1N 3BG London, UK</mods:affiliation></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation><mods:affiliation>Department of Neurosciences, University Hospital of Grenoble, INSERM 318, 38043 Grenoble, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Corresponding author. 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Thalamic DBS mainly improves contralateral tremor and is therefore restricted to a small group of patients with tremor dominant disease. STN and GPi DBS improve off-motor periods and dyskinesias. The magnitude of the improvement seems more constant with STN DBS than with GPi, but there is very little comparative data between these procedures. The DBS procedure has the unique advantage of reversibility and adjustability over time. Most authors agree that bilateral DBS is reasonably safe, which is not the case of ablation. In any event, surgery is restricted to patients disabled by their condition but still responding well at times to levodopa, who are generally fit with no behavioural, mood or cognitive impairment. DBS can have side effects. Side effects more specific to the DBS procedure are infection, disconnection and hardware failure. DBS, like ablative surgery can induce an intracranial lesion like a hematoma or a stroke. There are side effects more specific to the target like postural instability, dysarthria or paresthesia in the thalamus and dyskinesias or eyelid opening apraxia in the STN. The mechanism by which high frequency DBS mimics the effect of ablation is not fully understood.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Patricia Dowsey-Limousin</name><affiliations><json:string>Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, WC1N 3BG London, UK</json:string></affiliations></json:item><json:item><name>Pierre Pollak</name><affiliations><json:string>Department of Neurosciences, University Hospital of Grenoble, INSERM 318, 38043 Grenoble, France</json:string><json:string>Corresponding author. Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, BP 217, 38043 Grenoble Cedex 9, France. Tel.: +33-476765791; fax: +33-476765631</json:string><json:string>E-mail: pierre.pollak@ujf-grenoble.fr</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Deep brain stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Thalamus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Internal pallidum</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Subthalamic nucleus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Surgical treatment</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Deep brain stimulation (DBS) is a neurosurgical treatment of severe forms of Parkinson's disease, already applied to three targets, the thalamus, the internal pallidum (GPi) and the subthalamic nucleus (STN). 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Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, BP 217, 38043 Grenoble Cedex 9, France. Tel.: +33-476765791; fax: +33-476765631</affiliation></author></analytic><monogr><title level="j">Clinical Neuroscience Research</title><title level="j" type="abbrev">CLIRES</title><idno type="pISSN">1566-2772</idno><idno type="PII">S1566-2772(00)X0005-9</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001"></date><biblScope unit="volume">1</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="521">521</biblScope><biblScope unit="page" to="526">526</biblScope></imprint></monogr><idno type="istex">DB8891786BF537B5B60452C25BC70502061DF52E</idno><idno type="DOI">10.1016/S1566-2772(01)00029-9</idno><idno type="PII">S1566-2772(01)00029-9</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2001</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Deep brain stimulation (DBS) is a neurosurgical treatment of severe forms of Parkinson's disease, already applied to three targets, the thalamus, the internal pallidum (GPi) and the subthalamic nucleus (STN). Thalamic DBS mainly improves contralateral tremor and is therefore restricted to a small group of patients with tremor dominant disease. STN and GPi DBS improve off-motor periods and dyskinesias. The magnitude of the improvement seems more constant with STN DBS than with GPi, but there is very little comparative data between these procedures. The DBS procedure has the unique advantage of reversibility and adjustability over time. Most authors agree that bilateral DBS is reasonably safe, which is not the case of ablation. In any event, surgery is restricted to patients disabled by their condition but still responding well at times to levodopa, who are generally fit with no behavioural, mood or cognitive impairment. DBS can have side effects. Side effects more specific to the DBS procedure are infection, disconnection and hardware failure. DBS, like ablative surgery can induce an intracranial lesion like a hematoma or a stroke. There are side effects more specific to the target like postural instability, dysarthria or paresthesia in the thalamus and dyskinesias or eyelid opening apraxia in the STN. The mechanism by which high frequency DBS mimics the effect of ablation is not fully understood.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Deep brain stimulation</term></item><item><term>Thalamus</term></item><item><term>Internal pallidum</term></item><item><term>Subthalamic nucleus</term></item><item><term>Parkinson's disease</term></item><item><term>Surgical treatment</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2001-08-20">Registration</change><change when="2001-08-09">Modified</change><change when="2001">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="rev" xml:lang="en"><item-info><jid>CLIRES</jid><aid>51</aid><ce:pii>S1566-2772(01)00029-9</ce:pii><ce:doi>10.1016/S1566-2772(01)00029-9</ce:doi><ce:copyright type="full-transfer" year="2001">Elsevier Science B.V.</ce:copyright></item-info><head><ce:title>Deep brain stimulation in the treatment of Parkinson's disease: a review and update</ce:title><ce:author-group><ce:author><ce:given-name>Patricia</ce:given-name><ce:surname>Dowsey-Limousin</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Pierre</ce:given-name><ce:surname>Pollak</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:e-address>pierre.pollak@ujf-grenoble.fr</ce:e-address></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, WC1N 3BG London, UK</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Department of Neurosciences, University Hospital of Grenoble, INSERM 318, 38043 Grenoble, France</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Corresponding author. Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, BP 217, 38043 Grenoble Cedex 9, France. Tel.: +33-476765791; fax: +33-476765631</ce:text></ce:correspondence></ce:author-group><ce:date-received day="3" month="8" year="2001"></ce:date-received><ce:date-revised day="9" month="8" year="2001"></ce:date-revised><ce:date-accepted day="20" month="8" year="2001"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Deep brain stimulation (DBS) is a neurosurgical treatment of severe forms of Parkinson's disease, already applied to three targets, the thalamus, the internal pallidum (GPi) and the subthalamic nucleus (STN). Thalamic DBS mainly improves contralateral tremor and is therefore restricted to a small group of patients with tremor dominant disease. STN and GPi DBS improve off-motor periods and dyskinesias. The magnitude of the improvement seems more constant with STN DBS than with GPi, but there is very little comparative data between these procedures. The DBS procedure has the unique advantage of reversibility and adjustability over time. Most authors agree that bilateral DBS is reasonably safe, which is not the case of ablation. In any event, surgery is restricted to patients disabled by their condition but still responding well at times to levodopa, who are generally fit with no behavioural, mood or cognitive impairment. DBS can have side effects. Side effects more specific to the DBS procedure are infection, disconnection and hardware failure. DBS, like ablative surgery can induce an intracranial lesion like a hematoma or a stroke. There are side effects more specific to the target like postural instability, dysarthria or paresthesia in the thalamus and dyskinesias or eyelid opening apraxia in the STN. The mechanism by which high frequency DBS mimics the effect of ablation is not fully understood.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword" xml:lang="en"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Deep brain stimulation</ce:text></ce:keyword><ce:keyword><ce:text>Thalamus</ce:text></ce:keyword><ce:keyword><ce:text>Internal pallidum</ce:text></ce:keyword><ce:keyword><ce:text>Subthalamic nucleus</ce:text></ce:keyword><ce:keyword><ce:text>Parkinson's disease</ce:text></ce:keyword><ce:keyword><ce:text>Surgical treatment</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Deep brain stimulation in the treatment of Parkinson's disease: a review and update</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Deep brain stimulation in the treatment of Parkinson's disease: a review and update</title></titleInfo><name type="personal"><namePart type="given">Patricia</namePart><namePart type="family">Dowsey-Limousin</namePart><affiliation>Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, WC1N 3BG London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pierre</namePart><namePart type="family">Pollak</namePart><affiliation>Department of Neurosciences, University Hospital of Grenoble, INSERM 318, 38043 Grenoble, France</affiliation><affiliation>Corresponding author. Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, BP 217, 38043 Grenoble Cedex 9, France. 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Thalamic DBS mainly improves contralateral tremor and is therefore restricted to a small group of patients with tremor dominant disease. STN and GPi DBS improve off-motor periods and dyskinesias. The magnitude of the improvement seems more constant with STN DBS than with GPi, but there is very little comparative data between these procedures. The DBS procedure has the unique advantage of reversibility and adjustability over time. Most authors agree that bilateral DBS is reasonably safe, which is not the case of ablation. In any event, surgery is restricted to patients disabled by their condition but still responding well at times to levodopa, who are generally fit with no behavioural, mood or cognitive impairment. DBS can have side effects. Side effects more specific to the DBS procedure are infection, disconnection and hardware failure. DBS, like ablative surgery can induce an intracranial lesion like a hematoma or a stroke. There are side effects more specific to the target like postural instability, dysarthria or paresthesia in the thalamus and dyskinesias or eyelid opening apraxia in the STN. The mechanism by which high frequency DBS mimics the effect of ablation is not fully understood.</abstract><subject lang="en"><genre>Keywords</genre><topic>Deep brain stimulation</topic><topic>Thalamus</topic><topic>Internal pallidum</topic><topic>Subthalamic nucleus</topic><topic>Parkinson's disease</topic><topic>Surgical treatment</topic></subject><relatedItem type="host"><titleInfo><title>Clinical Neuroscience Research</title></titleInfo><titleInfo type="abbreviated"><title>CLIRES</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">200112</dateIssued></originInfo><identifier type="ISSN">1566-2772</identifier><identifier type="PII">S1566-2772(00)X0005-9</identifier><part><date>200112</date><detail type="issue"><title>Advances in Parkinson's Disease Research</title></detail><detail type="volume"><number>1</number><caption>vol.</caption></detail><detail type="issue"><number>6</number><caption>no.</caption></detail><extent unit="issue pages"><start>405</start><end>540</end></extent><extent unit="pages"><start>521</start><end>526</end></extent></part></relatedItem><identifier type="istex">DB8891786BF537B5B60452C25BC70502061DF52E</identifier><identifier type="DOI">10.1016/S1566-2772(01)00029-9</identifier><identifier type="PII">S1566-2772(01)00029-9</identifier><accessCondition type="use and reproduction" contentType="">© 2001Elsevier Science B.V.</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Elsevier Science B.V., ©2001</recordOrigin></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/DB8891786BF537B5B60452C25BC70502061DF52E/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">CLINICAL NEUROLOGY</classCode><classCode scheme="WOS">NEUROSCIENCES</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments></istex></record>Pour manipuler ce document sous Unix (Dilib)
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